2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- Product Name
- 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- CAS No.
- 150493-34-8
- Chemical Name
- 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- Synonyms
- NS 638;NS638, >98%;NS-638;NS 638;2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine;1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine;1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-;Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
- CBNumber
- CB11344812
- Molecular Formula
- C15H11ClF3N3
- Formula Weight
- 325.72
- MOL File
- 150493-34-8.mol
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Property
- Boiling point:
- 476.3±55.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
- form
- A solid
- pka
- 5.15±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-6337
- Product name
- NS-638
- Purity
- >98.0%
- Packaging
- 2mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-6337
- Product name
- NS-638
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-6337
- Product name
- NS-638
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-6337
- Product name
- NS-638
- Purity
- >98.0%
- Packaging
- 25mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- CS-6337
- Product name
- NS-638
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $470
- Updated
- 2021/12/16
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Chemical Properties,Usage,Production
Biological Activity
NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM.
in vivo
In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.
target
IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation)
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Suppliers
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